:warning: Please keep in mind that the z-scores are calculated using only patient data. Hence, 'mRNA High' in this case implies higher expression than the average patient. Also, the source data on which the z-score data is based does not necessarily follow the normal distribution. If your data does not follow the normal distribution, the z-score threshold is less reliable and will result in more false positives or false negatives. You can consider log transforming your value before calculating z-scores to improve this. However, even the logged values may not follow the normal distribution, especially if the data is bimodal.